Positive Quality Interventions Help Optimize Drug Therapy and Patient Outcomes

In an effort to promote higher quality patient care NCODA, Inc, created the NCODA Positive Quality Intervention (PQI) as a peer-reviewed clinical guidance document for healthcare providers.  By providing Quality Standards and effective practices around a specific aspect of cancer care, PQIs equip the entire multidisciplinary care team with a sophisticated yet simple-to-use resource for managing patients receiving oral or IV oncolytics. The PQI fosters better care for patients through appropriate patient identification, treatment selection, increased speed to therapy, reduced cost and hospitalization and by improving adherence techniques for the patient and their medically integrated teams.

The treatment and management of oncology patients on oral drug therapy is continually changing and evolving. The growing complexity creates a need for healthcare professionals to have a quick resource to turn to for drug therapy management information. The medically integrated pharmacy team is in a unique position to ensure appropriate treatment, increase compliance, and maximize outcomes. Positive Quality Interventions (PQIs), an NCODA Quality Standard, are designed to operationalize and standardize those practices to achieve these positive clinical outcomes. We welcome other professionals to join the PQI Committee and contribute relevant topics and potential authors to this growing body of knowledge and, in that way, better serve all patients living with cancer.

Recently Released PQIs

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Management of Abemaciclib (Verzenio®) Associated Diarrhea

Written by: Derek Gyori, PharmD and Julianne Orr, PharmD

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Advanced Breast Cancer: Appropriate Patient Identification with Abemaciclib (Verzenio®)

Written by: Jan Montgomery, PharmD, South Carolina Oncology Associates and Jacob Dygert, South University School of Pharmacy

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Acalabrutinib (Calquence®) in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Written by: Trey McNiel, PharmD, Georgia Cancer Specialists

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Afatinib (Gilotrif®) Management for Non-Small Cell Lung Cancer

Written by: Chris Sellers, RPh, Texas Oncology

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Management of Alpelisib (Piqray®) Induced Hyperglycemia

Written by: Natasha Khrystolubova, RPh, BCOP, Florida Cancer Specialists and Jody Agena, PharmD, Virginia Cancer Specialists

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Avapritinib (Ayvakit®) Management for Advanced Systemic Mastocytosis

Written by: Andrew Kuykendall, MD; Katherine Tobon, PharmD, BCOP; Syeda Saba Kareem PharmD, BCOP

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Avapritinib (Ayvakit®) Management for Gastrointestinal Stromal Tumor

Written by: Joshua Nubla, PharmD, NCODA

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Bortezomib (Velcade®) Management for Multiple Myeloma and Mantle Cell Lymphoma

Written by: Joshua Nubla, PharmD, NCODA

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Brentuximab Vedotin (Adcetris®): Neuropathy and Neutropenia Management

Written by: Kirollos Hanna, PharmD, BCPS, BCOP, Mayo Clinic College of Medicine and M Health Fairview and Kayla Randle, PharmD, BCOP, Kaiser Permanente – Southwood Oncology Clinic

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Cabazitaxel (Jevtana®) for Patients with Metastatic Castration-Resistant Prostate Cancer

Written by: Alyson Leonard, PharmD, BCPS, BCOP, Cone Health

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CDK4/6 Inhibitors in HR+/HER2- Advanced Breast Cancer

Written by: Ann Schwemm, PharmD, MPH, BCOP, University of Minnesota Health

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Cemiplimab-rwlc (Libtayo®) Patient Management

Written by: Marko Skelin MPharm PhD, Assistant Professor, Faculty of Medicine, University of Rijeka

Luis Raez, MD, FACP, Memorial Cancer Institute/Memorial Health Care System

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Copanlisib (Aliqopa) for the Management of Relapsed/Refractory Follicular Lymphoma

Written by: Andrew Kowalski, PharmD, and Osama Abdelghany, PharmD, MHA, BCOP, Smilow Cancer Hospital at Yale New Haven Health 

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Copanlisib (Aliqopa) Toxicity Management

Written by: Lauren Held, PharmD, BCOP, Seattle Cancer Care Alliance

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Daratumumab (Darzalex®) for Multiple Myeloma

Written by: Lauren Trisler, PharmD, BCOP, Carle Cancer Center

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Darolutamide (Nubeqa®) in the Treatment of Non-Metastatic Castration Resistant Prostate Cancer

Written by: Michelle Phillips, PharmD, BCOP, Wilmot Cancer Center 

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Liposomal Daunorubicin-Cytarabine (Vyxeos®) Management

Written by: Anna Howard, PharmD, BCOP, Billings Clinic

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Oral Formulation of Decitabine and Cedazuridine (Inqovi®) for Hematological Malignancies

Written by: Yonatan Resnick, PharmD, New England Cancer Specialists

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Durvalumab (Imfinzi®) Therapy Overview

Written by: Joshua Nubla, PharmD, NCODA

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Duvelisib (Copiktra®) for Chronic Lymphocytic Leukemia and Follicular Lymphoma

Written by: Linda Frisk, PharmD, Ironwood Cancer and Research Centers

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Enfortumab Vedotin (Padcev®) Management for Advanced or Metastatic Urothelial Carcinoma

Written by: Andrew Ruplin, PharmD, Seattle Cancer Care Alliance

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Enzalutamide (Xtandi®) for patients with castration-resistant prostate cancer or metastatic castration-sensitive prostate cancer

Written by: Samantha Larson, PharmD M Health Fairview

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Stomatitis Prophylaxis During Everolimus (Afinitor®) Therapy

Written by: Matthew Schulz, RPh Rocky Mountain Cancer Centers

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Fam-Trastuzumab deruxtecan-nxkiFam-Trastuzumab Deruxtecan-nxki (Enhertu®) Management

Written by: Brandy Persson, PharmD, BCPS, BCOP and Rebecca Fanning, PharmD, BCPS, Cone Health

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Fostamatinib (Tavalisse®) Use In Chronic Immune Thrombocytopenia

Written by: Julianne Darling, PharmD, BCOP, Indiana University Health Simon Cancer Center

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Written by: Bryan J. Brinda, PharmD, Indiana University Simon Cancer Center

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Granisetron (Sancuso®) Transdermal System for Chemotherapy Induced Nausea and Vomiting

Written by: Latha Radhakrishnan, PharmD, BCPS, BCOP, University of Illinois Hospital and Health Sciences System

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Ibrutinib (Imbruvica®) Expansion with Obinutuzumab (Gazyva®)

Written by: Tammy McClellan, PharmD, Riverside Healthcare

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Ibrutinib (Imbruvica®) Management

Written by: Jody Agena, PharmD, MBA, BCOP

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Isatuximab-irfc (Sarclisa®) In Patients with Relapsed Refractory Multiple Myeloma

Written by: Jon Suyko Pharm.D., BCPS UCHealth Highlands Ranch

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Ixazomib (Ninlaro®) In the Treatment of Multiple Myeloma

Written by: Kirollos Hanna, PharmD, BCPS, BCOP, University of Minnesota Medical Center & Mayo Clinic

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Non-hormonal Birth Control Alternative with Lactic acid/Citric acid/Potassium Bitartrate (Phexxi®)

Written by: Natasha Olson, PharmD, NCODA

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Larotrectinib (Vitrakvi®) Overview

Written by: Elizabeth Ledbetter, PharmD, Indiana University Health

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Larotrectinib (Vitrakvi®) Genomic Testing Management

Written by: Joshua Nubla, PharmD, NCODA

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Loncastuximab tesirine-lply (Zynlonta®) in Relapsed/Refractory Large B-Cell Lymphoma

Written by: Kelly Valla, PharmD, BCOP, Emory Healthcare Winship Cancer Institute

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Lurbinectedin (ZepzelcaTM) for Small Cell Lung Cancer

Written by: Luis E. Raez, MD, FACP

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Mobocertinib (Exkivity™) Side Effect Management

Written by: Danny Nguyen, MD, Nishan Tchekmedyian, MD, André K.D. Liem, MD, City of Hope National Medical Center

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Neratinib (Nerlynx®) Diarrhea Management

Written by: Eric Dallara, RPh, New England Cancer Specialist

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Netupitant/Fosnetupitant and Palonosetron (Akynzeo®) for Chemotherapy-Induced Nausea and Vomiting

Written by: Doug Braun, PharmD and Emily Gallagher, PharmD | AON

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Niraparib (Zejula): Dose Modifications Based on Weight and Platelet Counts

Written by: Michelle Phillips, PharmD, University of Rochester Medical Center

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Olanzapine (Zyprexa®) In Chemotherapy Induced Nausea and Vomiting

Written by: Julianne Orr, PharmD, Indiana University Health Simon Cancer Center

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Written by: Katie Carter, PharmD, BCPS, Indiana University Health

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Written by: Alyson Leonard, PharmD, BCPS, BCOP, Cone Health 

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PARP Inhibitor for Ovarian Cancer

Written by: Martina Fraga, PharmD, Henry Ford Cancer Institute

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Pralsetinib (Gavreto®) Management for Metastatic RET Fusion-Positive Non-Small Cell Lung Cancer

Written by: Kayla Randle, PharmD, BCOP Kaiser Permanente of Georgia

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Use of Rasburicase (Elitek®) for Treatment of Tumor Lysis Syndrome

Written by: Marie C. Rush, PharmD, CPP, BCOP, Wake Forest Baptist Health

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Regorafenib (Stivarga®) In the Treatment of Hepatocellular Carcinoma

Written by: Jody Agena, PharmD, Virginia Cancer Specialists

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Regorafenib (Stivarga®) in Metastatic Colorectal Cancer

Written by: Neal Dave, PharmD, Texas Oncology; Natasha Khrystolubova, RPh, BCOP, Florida Cancer Specialists 

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Ripretinib (Qinlock®) for Treatment of Adults with Advanced Gastrointestinal Stromal Tumors

Written by: Joseph Bubalo PharmD, Oregon Health & Science University

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Use of Rucaparib (Rubraca®) In the Treatment of Ovarian, Fallopian Tube, Primary Peritoneal or Prostate Cancer

Written by: Jon Suyko Pharm.D., BCPS, UCHealth Highlands Ranch

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Ruxolitinib (Jakafi®) – Managing Myelofibrosis Patients

Written by: Todd Murphree, PharmD, Clearview Cancer Institute

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Ruxolitinib (Jakafi®): Managing Treatment of Polycythemia Vera

Written by: Neal Dave, PharmD, Texas Oncology 

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Selinexor (Xpovio®) Patient Management

Written by: Jeremiah Moore, PharmD, University of Rochester Medical Center

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Selpercatinib (Retevmo®) Management

Written by: Joshua Nubla, PharmD, NCODA

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Selpercatinib (Retevmo®) Genomic Testing Management

Written by: Joshua Nubla, PharmD, NCODA

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Sorafenib (Nexavar®) for the Treatment of Hepatocellular Carcinoma and Transition to Second-line Regorafenib (Stivarga®)

Written by: Jeff Engle, PharmD, MS University of Minnesota Masonic Cancer Clinic

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Tafasitamab (Monjuvi®) for Diffuse Large B-Cell Lymphoma

Written By: Jeff Engle, PharmD, MS, M Health Fairview University of Minnesota Medical Center

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Tazemetostat (Tazverik®) Management in Relapsed/Refractory Follicular Lymphoma 

Written by: Houston Holmes, MD, Texas Oncology

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Telotristat Ethyl (Xermelo®) for the Management of Carcinoid Syndrome Diarrhea

Written by: Lisa Raff, PharmD, BCPS, BCOP Northwest Oncology & Hematology

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Trifluridine and Tipiracil (Lonsurf®) for Treatment of Gastric Cancer

Written by: Isabel Houlzet, PharmD, BCPS, BCOP Miami Cancer Institute

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Trifluridine and Tipiracil (Lonsurf®) for Metastatic Colorectal Cancer

Written by: Jennifer M. Hasiak O’Doherty, PharmD, Hematology Oncology Consultants, PC

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Trilaciclib (Cosela™) Management

Written by: Autumn Alvarez, PharmD, BCPS, Blue Ridge Cancer Care

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Tucatinib (Tukysa®) Management

Written by: Katie Carter, PharmD, BCPS, IU Simon Cancer Center

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Umbralisib (Ukoniq®) Patient Management

Written By: Jeremiah Moore, PharmD, BCOP

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Venetoclax (Venclexta®) Risk Stratification, Dosing, and Dispensing Procedure

Written by: Jon Suyko, PharmD, BCPS UCHealth Highlands Ranch

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Zanubrutinib (Brukinsa®) Patient Selection and Management in Mantle Cell Lymphoma

Written by: Kayla Randle, PharmD, BCOP Kaiser Permanente Georgia Oncology

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Chemotherapy, Oncolytic, Antiemetic Induced Constipation

Written by: Brady Quinn and Britny Rogala, PharmD – University of Rhode Island College of Pharmacy

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Opioid Induced Constipation

Written by: Neal Dave, PharmD and Julianne Orr, PharmD – Texas Oncology and Indiana University

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Oncolytic Induced Diarrhea

Written by: Joshua Nubla, PharmD, NCODA

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Medication Induced Hand-Foot Syndrome

Written by: Jonas Congelli, RPh, Hematology Oncology Associates of CNY 

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Chemotherapy-Induced Nausea and Vomiting

Written by: Kirollos S. Hanna, PharmD, BCPS, BCOP, University of Minnesota Medical Center & Mayo Clinic

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Chemotherapy Induced Peripheral Neuropathy

Written by: Andrea Clarke, PharmD and Becky Fahrenbruch, PharmD, BCOP, University of Minnesota Health

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Managing Immunotherapy Treatment Related Rash

Written by: Natasha Heimbigner, PharmD, Summit Cancer Centers

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Vaccination for Non-Transplant Patients with Cancer

Written by: Michelle Hoa and Natasha Heimbigner, PharmD, Summit Cancer Centers

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Advanced Systemic Mastocytosis Patient Diagnostic Algorithm

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Written by: Prithviraj Bose, MD, UT MD Anderson Cancer Center

Chronic Lymphocytic Leukemia and Del17p

Written by: Danny Olszta, PharmD, BCOP, Jolliet Oncology Hematology Associates 

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Non-Small Cell Lung Cancer Stage III Overview and Patient Eligibility of Durvalumab (Imfinzi®)

Written by: Joshua Nubla, PharmD, NCODA

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Patient Screening for Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)

Written by: Tammy McClellan, PharmD, Riverside Healthcare

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Proactive Symptom Management in Myelofibrosis

Written by: Kristyn DiSogra, PharmD, BCOP and Justin Arnall, PharmD, BCOP, Atrium Health

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PQI Submissions

PQIs are created and written by NCODA members. If you have a relevant topic that highlights a specific aspect of cancer patient care, please contact us for consideration of authorship and incorporation into our library of best practices.

NCODA PQI Clinical Committee

Kirollos Hanna, PharmD, BCPS, BCOP | University of Minnesota Medical Center & Mayo Clinic, MN (Chief Editor)

Michelle Phillips, PharmD, BCOP | UR Specialty Pharmacy, NY (Chair)

Kayla Boyd, PharmD, BCOP | Kaiser Permanente, GA (Chair)

Jen Hasiak, PharmD | Hematology & Oncology Consultants Pharmacy, NE

Jody Agena, PharmD, MBA, BCOP | Virginia Cancer Specialists, VA

Jon Suyko, PharmD | UC Health Highlands Ranch, CO

Lauren Trisler, PharmD | Carle, IL

Shanada Monestime, PharmD, BCOP | Baptist Health, FL

Lawrence Garbo, MD | New York Oncology Hematology, NY (Physician Medical Reviewer)

Wayne Ormsby, MD | Utah Cancer Specialists, UT (Physician Medical Reviewer)

Natasha Olson, PharmD | NCODA

PQI CORPORATE SPONSORS

NCODA recognizes our PQI corporate sponsors who demonstrate their continued commitment and support to helping NCODA members through this beneficial educational platform.

Important Notice: National Community Oncology Dispensing Association, Inc. (NCODA), has developed this Positive Quality Intervention platform. This platform represents a brief summary of medication uses and therapy options derived from prescribing information and primary clinical literature as well as supplementary third party resources. This platform is intended as an educational aid and does not provide individual medical advice and does not substitute for the advice of a qualified healthcare professional. This platform does not cover all existing information related to the possible uses, directions, doses, precautions, warning, interactions, adverse effects, or risks associated with the medication discussed in the platform and is not intended as a substitute for the advice of a qualified healthcare professional. The materials contained in this platform are for informational purposes only and do not constitute or imply endorsement, recommendation, or favoring of this medication by NCODA, which assumes no liability for and does not ensure the accuracy of the information presented. NCODA does not make any representations with respect to the medications whatsoever, and any and all decisions, with respect to such medications, are at the sole risk of the individual consuming the medication. All decisions related to taking this medication should be made with the guidance and under the direction of a qualified healthcare professional.