CLL Microlearning Series – Video #2: Considerations for 1st Line Therapy
Considerations for 1st Line Therapy
As CLL management continues to evolve, recognizing the right moment to transition from observation to treatment remains a critical skill for clinicians.
This short module highlights the practical, real-world cues that signal true disease progression—ensuring therapy begins at the appropriate time and for the right reasons. An APP specializing in CLL walks through how to interpret clinical symptoms, lab trends, and iwCLL criteria in everyday practice.
In This Video, You’ll Learn How To:
- The common triggers for starting CLL therapy, including symptomatic disease or lab-based progression
- How marrow infiltration leads to progressive cytopenias—and why these often prompt treatment
- Key symptoms of bulky lymphadenopathy and splenomegaly that warrant intervention
- When refractory autoimmune cytopenias indicate the need for CLL-directed therapy
- Why iwCLL guidelines remain the standard for determining medically appropriate treatment timing