25

May

Proactive Symptom Management in Myelofibrosis

Written by: Kristyn DiSogra, PharmD, BCOP and Justin Arnall, PharmD, BCOP, Atrium Health
Download Here

The purpose of this PQI is to highlight implementation of telehealth symptom and risk survey completion by pharmacists or other healthcare providers for myelofibrosis (MF) patients. The goal is to improve provider clinical care pathway adherence and treatment optimization in MF patients.

Background:

Patients diagnosed with MF may have a symptom burden that compromises patient quality of life. Myelofibrosis is one of the classical Philadelphia chromosome negative myeloproliferative neoplasms (MPNs). The only curative treatment option is allogeneic hematopoietic stem cell transplantation, which is associated with significant risks and can only be administered to a minority of patients based on disease risk category and age. Other treatment options have been historically focused on alleviation of the symptoms that are present for each individual patient but do not alter the course of the disease itself.1-2 

Multiple studies have led to the development and validation of a patient MPN-related symptom burden questionnaire that can be used for serial assessments of response to therapy. The Myeloproliferative Neoplasm Symptom Assessment Form total symptom score (MPN-SAF TSS) was calculated as the mean score for 10 items from two previously validated scoring systems with questions to assess symptoms of fatigue, concentration, early satiety, inactivity, night sweats, itching, bone pain, abdominal discomfort, weight loss, and fevers. Scoring is from 0 (symptom absent) to 10 (worst imaginable) for each symptom assessed. The final score is the summation of all of the 10 symptom scores on a 0 to 100 scale.2  In addition to symptom assessment utilizing the MPN-SAF TSS, a risk scoring system, the Dynamic International Prognostic Scoring System (DIPSS-Plus) has been developed to be a dynamic risk assessment tool that can be used at diagnosis and anytime during the course of therapy to attempt to predict survival.3 The DIPSS-Plus risk score is a prognostic tool evaluating age, blood counts, peripheral blood blast percentage, karyotype, transfusion dependency, and presence of constitutional symptoms to tabulate a combined score to assign low, intermediate-1, intermediate-2, and high-risk categories to MPN patients.3

Guidelines recommend evaluation of patients’ symptom burden and prognostic risk scores prior to initiation of therapy and at a regular intervals during the course of therapy, typically every 3 to 6 months during clinical encounters. Symptom response defined by the International Working Group-Myeloproliferative Neoplasms Research and Treatment and the European LeukemiaNet consensus report requires a greater than or equal to 50% reduction in the MPN-SAF TSS sustained for at least 12 weeks.4 Providers utilize both the MPN-SAF TSS and DIPSS-Plus as tools upon diagnosis and throughout therapy to guide treatment, to assess when changes in therapy are needed, and occasionally to assess the optimal timing of allogeneic hematopoietic stem cell transplantation. However, the traditional approach to obtaining these assessments, during clinic visits, may be burdensome for many patients and providers given limited time and other resources as well as patient needs for these visits. A recent analysis has additionally demonstrated that risk prognostication is often done incorrectly so there may be a need to identify mechanisms to perform these assessments in a correct, standardized, and uniform manner.5

Performing the MPN-SAF TSS and DIPSS-Plus assessments prior to clinic appointments offers enhanced efficiency of clinic time and allows MF providers to create therapy plans prior to patients’ clinic appointments. A pharmacist-driven telehealth consult program at Atrium Health was developed to an increase adherence to internal care pathways/national guideline recommendations and led to care optimization for MF patients. This consult service represents an opportunity for the outpatient and specialty pharmacy services to be incorporated into the care pathways for MF patients as an element of standard of care and demonstrates a shift towards a pharmacy practice-based model. By implementing this service, pharmacists have had an active and leading role in virtual care which has become more relevant as a result of  the COVID-19 pandemic.6

PQI Process:

  • Upon diagnosis or clinical review of a MF patient, the patient should be flagged by the provider for symptom and risk assessments to be completed at baseline and a predefined interval with corresponding physician visits
  • A pharmacy consult service can be established to utilize multidisciplinary approach for long-term patient follow-up and assessment completion
    • MPN-SAF TSS symptom and DIPSS-Plus risk assessments for MF can be completed in person or via telephone for patients prior to their provider appointments (in-person or virtual) and then uploaded via the electronic medical record for the provider to review prior to the upcoming appointment.
  • If a pharmacy consult is established, the following workflow can be mimicked or translated into best practice for your institution:

  • Providers identify patients and initiate a consult through a consult order
    • The consult triggers an order to be sent to the pharmacy queue or triggers an email to be sent to the pharmacy team
    • The patient is notified of enrollment by the provider prior to pharmacist contact
  • A system should be developed to track the patients in two manners
    • The number of times patient has been contacted to complete the assessments
    • The date of the previous assessments to make sure the patient is contacted at the correct interval
  • Once consulted, the pharmacist attempts to complete both the MPN-SAF TSS and DIPSS-Plus risk score assessments
    • MPN-SAF TSS questions are completed with patient consent via telephone
      • Three phone call attempts are completed by the pharmacist
    • Once the MPN-SAF TSS is completed and the confirmation of presence or absence of constitutional symptoms is confirmed, the DIPSS-Plus risk assessment can be completed using the most recent laboratory values and karyotype information
  • Completed assessments via the pharmacy consult service are scanned into the EMR prior to the patient’s next clinic appointment
  • Provider is notified via the EMR of the importation and assessment location of the assessment
    • If the patient was not reached, the pharmacists notifies the provider which then prompts the provider to complete the assessments during the clinic appointment, thereby reinforcing adherence to the guideline recommendations via a multidisciplinary approach
  • Patients are contacted at 3-month, 6-month, or 12-month intervals corresponding with their planned follow-up schedule with the physician based on disease stability to adhere to guideline recommendations

Patient Centered Activities:

  • With the establishment of a telehealth consult for the MPN-SAF TSS and DIPSS-Plus assessments, patients are provided with the opportunity to streamline their discussion with their provider at upcoming clinic appointments
  • Patients to receive Oral Chemotherapy Education (OCE) for applicable medications that may be prescribed for their MF
  • Patient medication adherence can be assessed with completion of the MPN-SAF TSS assessment
  • Medication issues (ex. drug-drug interactions, non-adherence, etc.) can be identified by the pharmacist and relayed to the provider with additional patient interaction through completion of the MF assessments

References:

  1. Cervantes F. How I treat myelofibrosis. 2014;124(17):2635-42.
  2. Emanuel RM, Dueck AC, Geyer HL, et al. Myeloproliferative neoplasm (MPN) symptom assessment form total symptom score: prospective international assessment of an abbreviated symptom burden scoring system among patients with MPNs. J Clin Oncol. 2012;30(33):4098-103.
  3. Passamonti F, Cervantes F, Vannucchi AM, et al. A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment). Blood. 2010;115(9):1703-8.
  4. National Comprehensive Cancer Network. Myeloproliferative Neoplasms (Version 1.2021). https://www.nccn.org/professionals/physician_gls/pdf/mpn.pdf. Accessed April 16, 2021.
  5. Verstovsek S, Yu J, Kish JK, et al. Real-world risk assessment and treatment initiation among patients with myelofibrosis at community oncology practices in the United States. Ann Hematol. 2020; 99(11):2555-2564.
  6. Yemm KE, Arnall JR, Cowgill NA. Necessity of Pharmacist-driven non-prescription telehealth consult services in the era of COVID-19. Am J Health Syst Pharm. 2020; 77(15): 1188. Doi: 10.1093/ajhp/zxaa162.
Important notice: National Community Oncology Dispensing Association, Inc. (NCODA), has developed this Positive Quality Intervention platform. This platform represents a brief summary of medication uses and therapy options derived from information provided by the drug manufacturer and other resources. This platform is intended as an educational aid and does not provide individual medical advice and does not substitute for the advice of a qualified healthcare professional. This platform does not cover all existing information related to the possible uses, directions, doses, precautions, warning, interactions, adverse effects, or risks associated with the medication discussed in the platform and is not intended as a substitute for the advice of a qualified healthcare professional. The materials contained in this platform are for informational purposes only and do not constitute or imply endorsement, recommendation, or favoring of this medication by NCODA, which assumes no liability for and does not ensure the accuracy of the information presented. NCODA does not make any representations with respect to the medications whatsoever, and any and all decisions, with respect to such medications, are at the sole risk of the individual consuming the medication. All decisions related to taking this medication should be made with the guidance and under the direction of a qualified healthcare professional.
Katie Edmiston

Katie Edmiston has blogged 10 posts

View all PQI