This article explores how the care teams at Florida Cancer Specialists & Research Institute, Texas Oncology, and Emory Healthcare|Winship Cancer Institute incorporate PQIs as part of their daily workflow and how the Pacritinib (VONJO®) in Cytopenic Myelofibrosis PQI in Action elevates patient care. The guide includes Pearls, The PQI Process, Background, Indications/Mechanism of Action/Clinical Research, Adverse Effect Management and Patient-Centered Activities.