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Management of Tucatinib (Tukysa®) and Trastuzumab in HER2-Positive Metastatic Colorectal Cancer

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Last Updated: July 28, 2025

By: Johns Hopkins, MD | The University of Texas MD Anderson Cancer Center, TX

About this PQI in Action

In an effort to promote higher quality patient care, NCODA created the NCODA Positive Quality Intervention (PQI) as a peer-reviewed clinical guidance resource for healthcare providers. By providing Quality Standards and effective practices around a specific aspect of cancer care, PQIs equip the entire multidisciplinary care team with a sophisticated yet concise resource for managing patients receiving oral or IV oncolytics. This PQI in Action explores how the medically integrated teams at the Ruesch Center for the Cure of GI Cancers at Georgetown University and University Hospitals Seidman Cancer Center incorporate the information found in the PQIs as part of their daily workflow. This article will discuss how utilizing the Tucatinib (TUKYSA®) and trastuzumab in HER2-positive Metastatic Colorectal Cancer PQI elevates patient care.