Written by: Kirollos Hanna, PharmD, BCPS, BCOP, Mayo Clinic College of Medicine and M Health Fairview and Kayla Randle, PharmD, BCOP, Kaiser Permanente – Southwood Oncology Clinic
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Brentuximab vedotin (Adcetris) is an CD30-directed antibody drug conjugate (ADC) indicated as front-line treatment for patients with classical stage III/IV Hodgkin’s Lymphoma (cHL) or CD30-expressing peripheral T-cell lymphomas (PTCL) in combination with multiagent chemotherapy.1 This PQI will review how to safely manage select toxicities associated with Brentuximab vedotin. Continue reading Brentuximab Vedotin: Neuropathy and Neutropenia Management

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Written by: Katie Carter, PharmD, BCPS, Indiana University Health
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Olaparib (Lynparza) is a poly ADP-ribose polymerase (PARP) enzyme inhibitor and is currently FDA approved as targeted therapy for BRCA-mutated breast cancer and ovarian cancer.  This PQI will highlight its place in therapy in these disease states, safety profiles, and clinical pearls regarding dose adjustment.
Continue reading Olaparib in BRCA-mutated Breast, Ovarian and Pancreatic Cancer

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Written by: Jeff Engle, PharmD, MS
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This PQI will discuss effective management of adverse effects of sorafenib (Nexavar) in the treatment of hepatocellular carcinoma and discuss data supporting the sequencing of patients to second-line therapy with regorafenib for increased survival benefit.

Continue reading Sorafenib for the Treatment of Hepatocellular Carcinoma and Transition to Second-line Regorafenib

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Written by: Martina Fraga, PharmD
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This purpose of this PQI is to highlight effective practices to ensure ovarian cancer patients are identified, tested, tracked, and offered a PARP inhibitor when appropriate.

Continue reading Ovarian Cancer: PARP Inhibitor Eligibility

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Written by: Jeremiah Moore, PharmD
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Selinexor (Xpovio®) is a novel medication for patients with relapsed, refractory multiple myeloma. This PQI will provide background on the novel mechanism of action and discuss effective practices to maximize the use of selinexor therapy.

Continue reading Selinexor Patient Management

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