Written by: Katie Carter, PharmD, BCPS, Indiana University Health
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Olaparib (Lynparza) is a poly ADP-ribose polymerase (PARP) enzyme inhibitor and is currently FDA approved as targeted therapy for BRCA-mutated breast cancer and ovarian cancer.  This PQI will highlight its place in therapy in these disease states, safety profiles, and clinical pearls regarding dose adjustment.
Continue reading Olaparib in BRCA-mutated Breast, Ovarian and Pancreatic Cancer

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Written by: Jeff Engle, PharmD, MS
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This PQI will discuss effective management of adverse effects of sorafenib (Nexavar) in the treatment of hepatocellular carcinoma and discuss data supporting the sequencing of patients to second-line therapy with regorafenib for increased survival benefit.

Continue reading Sorafenib for the Treatment of Hepatocellular Carcinoma and Transition to Second-line Regorafenib

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Written by: Martina Fraga, PharmD
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This purpose of this PQI is to highlight effective practices to ensure ovarian cancer patients are identified, tested, tracked, and offered a PARP inhibitor when appropriate.

Continue reading Ovarian Cancer: PARP Inhibitor Eligibility

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Written by Isabel Houlzet, PharmD, BCPS, BCOP, Miami Cancer Institute
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To increase awareness and management of adverse effects related to trifluridine/tipiracil treatment in metastatic colorectal cancer.

Continue reading Trifluridine / Tipiracil for Treatment of Gastric Cancer

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Written by: Bryan J. Brinda, PharmD
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This PQI will discuss proper patient selection and management of adverse events related to the administration of oral gilteritinib pharmacotherapy in patients with relapsed/refractory AML that have an FMS-like tyrosine kinase 3 (FLT3) mutation as detected by an FDA-approved test.  Optimal patient identification, dosing, and follow-up are essential to help patients benefit fully while taking this medication.
Continue reading Gilteritinib (XOSPATA) for Relapsed/Refractory Acute Myeloid Leukemia (AML)

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